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中药学院导师简介——李军

来源: 作者: 发布时间:2023-11-28

   

  个人简介:

  博士、研究员、博士研究生导师,北京中医药大学中药学院副院长。国家药典委员会委员,国家青年岐黄学者,教育部新世纪优秀人才,获中华中医药学会中青年创新人才奖。主要从事中药(民族药)药效物质、中药质量评价与质量控制研究。兼任《北京中医药大学学报》《中国中药杂志》《中草药》《中国医院用药评价与分析》编委,《Journal of Traditional Chinese Medical Sciences》《世界中医药》青年编委,中国中药协会精准中药专业委员会副主任委员,中国化学会高级会员,中华中医药学会中药化学分会委员,中国医疗保健国际交流促进会中药学分会委员。

  主要研究方向:

  1. 基于中药化学生物学的中药(民族药)防治心脑血管疾病药效物质与作用机制研究。

  2. 基于药效成分的中药整体质量评价与质量控制研究。

  科研成果:

  主持承担了国家重点研发计划、国家重大新药创制、国家自然科学基金等国家和省部级课题19项,系统开展了活血化瘀类、树脂类中药(民族药)防治心脑血管疾病药效物质与作用机制研究。成果获得国家科学技术技进步二等奖1项,教育部高等学校科学研究优秀成果自然科学二等奖1项。以第一或通讯作者发表论文127篇,其中在Org Lett,Anal Chem,Anal Chim Acta,J Adv Res,J Nat Prod等SCI杂志发表论文80篇,参编著作7部,获授权中国发明专利20项。

  代表性论文:

  1.Zhang H#, Ma JL#, Chang C, Ta H, Zhao YF, Shi SP, Song YL, Tu PF, Huo HX*, Zheng J*, Li J*. Gastroprotective 2-(2-phenylethyl)chromone-sesquiterpene hybrids from the resinous wood of Aquilaria sinensis (Lour.) Gilg. Bioorg Chem 2023, 133, 106396.

  2.Ma J#, Huo H#, Zhang H, Wang L, Meng Y, Jin F, Wang X, Zhao Y, Zhao Y, Tu P, Song Y*, Zheng J*, Li J*. 2-(2-Phenylethyl)chromone-enriched extract of the resinous heartwood of Chinese agarwood (Aquilaria sinensis) protects against taurocholic acid-induced gastric epithelial cells apoptosis through Perk/eIF2α/CHOP pathway. Phytomedicine 2022, 98, 153935.

  3.Qi B, Li N, Zhang B, Zhang Z, Wang W, Liu X, Wang J, Awakawa T, Tu P, Abe I*, Shi S*, Li J*. A multifunctional cytochrome P450 and a meroterpenoid cyclase in the biosynthesis of fungal meroterpenoid atlantinone B. Org Lett 2022, 24, 2526−2530.

  4.Liu W, Li W, Zhang P, Gong X, Tu P, Tang L*, Li J*, Song Y*. Quality structural annotation for the metabolites of chlorogenic acid in rat. Food Chem 2022, 379, 132134.

  5.Zhu ZX#, Wang LL#, Guo R, Pang DR, Wang WX, Wu Y, Li J*, Tu PF*. XJ-8, a natural compound isolated from Sanguis draxonis, inhibits platelet function and thrombosis by targeting MAP3K3. J Thromb Haemost 2022, 20, 605–618.

  6.Pan B#, Sun J#, Liu ZY, Wang LX, Huo HX, Zhao YF, Tu PF, Xiao W, Zheng J*, Li J*. Longxuetongluo Capsule protects against cerebral ischemia/reperfusion injury through endoplasmic reticulum stress and MAPK-mediated mechanisms. J Adv Res 2021, 33, 215–225.

  7.Xu X, Li W, Li T, Zhang K, Song Q, Liu L, Tu P, Wang Y, Song Y*, Li J*. Direct infusion–three-dimensional mass spectrometry enables rapid chemome comparison among herbal medicines. Anal Chem 2020, 92, 7646–7656.

  8.Guan PW, Song QQ, Li T, Cao LB, Tang HT, Wang YT, Tu PF, Zheng J*, Song YL*, Li  J*. Confirmative structural annotation for metabolites of (R)-7,3'-dihydroxy-4'-methoxy-8-methylflavane, a natural sweet taste modulator, by liquid chromatography-three-dimensional mass spectrometry. J Agric Food Chem 2020, 68(44):12454-12466.

  9.Liu WJ, Song QQ, Cao Y, Zhao YF, Huo HX, Wang YT, Song YL*, Li J*, Tu PF. Advanced liquid chromatography-mass spectrometry enables merging widely targeted metabolomics and proteomics. Anal Chim Acta 2019, 1069, 89–97.

  10.Huo HX, Zhu ZX, Song YL, Shi SP, Sun J, Sun H, Zhao YF, Zheng J, Ferreira D, Zjawiony JK, Tu PF, Li J*. Anti-inflammatory dimeric 2-(2-phenylethyl)chromones from the resinous wood of Aquilaria sinensis. J Nat Prod 2018, 81, 543–553.

  联系方式:

  E-mail: drlj666@163.com