所属学科名称：中药药理学

导师简介:赵保胜

个人简介：

赵保胜，男，中药药理学博士，研究员，博士研究生导师,博士后合作导师。就职于北京中医药大学北京中医药研究院，主要从事中医药抗糖尿病、肿瘤药效与机制研究、中药新药研发等工作。兼任国家自然科学基金委评审专家、中国民族医药学会药品临床评价分会常务理事、中国实验动物学会中医药实验动物专业委员会常务委员、中国实验方剂学杂志编委等职。

主持科研项目20余项，其中国家自然科学基金项目4项，新药研发项目10余项；发表学术论文100余篇，其中SCI论文40余篇；获国家发明专利、PCT专利5项。Journal of Ethnopharmacology、BMC Complementary and Alternative Medicine、Biomedicine & Pharmacotherapy、Phytotherapy Research等SCI杂志审稿专家，《中国实验方剂学杂志》编委。

主要研究方向：

1.中医药防治糖尿病、肿瘤药效与机制研究

2.中药新药研发

科研成果：

主持项目：

1. 国家自然科学基金面上项目，82274166，基于SCFAs-AMPK信号通路的桑叶“调控肠道菌群-诱导白色脂肪棕色化/棕色脂肪活化”治疗2型糖尿病作用机制及其活性成分垂钓研究：2023.01-2026.12，52万，在研，主持

2. 国家自然科学基金面上项目，81973535，基于“肠道菌群-SCFAs-GPR41/43-GLP-1”信号通路探讨桑叶调控肠道菌群治疗2型糖尿病作用及其机制：2020.01-2023.12，55万，已结题，主持

代表性论文：

1. Lu Shi, Yige Zhao, ……Baosheng Zhao*. Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling, Journal of Ethnopharmacology, 372 (2027) 122237, https://doi.org/10.1016/j.jep.2026.1222371

2. Yang Yang, Yige Zhao,……Baosheng Zhao*. Mulberry Leaf Water Extract Ameliorates Impaired Glucose Tolerance via the Gut Microbiota/SCFAs/AMPKα1 Axis in Adipose Tissue[J], Pharmaceuticals, 2026, 19, 1232. https://doi.org/10.3390/ ph19081232

3. Su Xiaohua, Du Yuhang, ……Baosheng Zhao*. 4-Methylesculetin Ameliorates Hepatic Insulin Resistance in HepG2 Cells Through AMPK/FOXO1, PI3K/AKT/GSK3β Pathways and SIRT1/NOX4 Axis[J], Journal of Diabetes Research, 2026:8023146. https://doi.org/10.1155/jdr/8023146

4. Jiamei Xie, Changhao He,……Baosheng Zhao*. Dual anti-inflammatory and analgesic effects of Xipayi Mouth Rinse on radiation-induced oral mucositis: ethnopharmacological and preclinical evidence.  Journal of Ethnopharmacology, 2026, 354:120501. https://doi.org/10.1016/j.jep.2025.120501

5. Yuhang Du, Changhao He, ……Baosheng Zhao*. Gut microbiota modified by mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway. Journal of Ethnopharmacology, https://doi.org/10.1016/j.jep.2025.120408

6. jiamei Xie, Yang Yang, ……Baosheng Zhao*. Investigation of Tongqiao jiuxin Oil AgainstHigh-Altitude Hypoxia: Integrating Chemical Profiling, Network Pharmacology, and Experimental Validation. Pharmaceuticals, 2025, 18, 1153 ttps://doi.org/10.3390/ph18081153

7. Wang M, Yang Y, ……Baosheng Zhao*. Analysis of chemical and blood transition components of Xi-Pa-Yi-Mai-Zi-Bi-Zi Oral Liquid and its excitatory purine regulation-mechanism study in treating overactive bladder[J]. Journal of Pharmacy and Pharmacology, 2025. https://doi.org/10.1093/jpp/rgaf011.

8. Yongcheng An, Hongbin Zhao, ……Baosheng Zhao*. Xiasangju alleviates hepatic insulin resistance in db/db mice via AMPK pathway: Mechanisms and active components study. International Immunopharmacology, 2025, 156:114675, doi.org/10.1016/j.intimp.2025.114675

联系方式：

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